Exelon Patch 5
Transdermal Patch
Generic Name
Rivastigmine Tartrate
Strength
4.6 mg/24 hr
Manufacturer
Nevian Lifescience PLC
Unit Price
Unit Price: ৳ 179.00 (1 x 30: ৳ 5,370.00)
Unit Price: ৳ 179.00 (1 x 30: ৳ 5,370.00)
✅ In Stock
per unit · Bangladesh
🛒 Buy Now
🔒 Secure checkout · Return & Refund Policy
🔹 Indications
Exelon Patch 5 capsule is indicated for the symptomatic treatment of mild to moderately severe Alzheimer's dementia. Symptomatic treatment of mild to moderately severe dementia in patients with Idiopathic Parkinson's disease.
🔹 Pharmacology
Rivastigmine is a carbamate derivative that is structurally related to physostigmine, but not to donepezil and tacrine. The precise mechanism of rivastigmine has not been fully determined, but it is suggested that rivastigmine binds reversibly with and inactivates chlolinesterase (eg. acetylcholinesterase, butyrylcholinesterase), preventing the hydrolysis of acetycholine, and thus leading to an increased concentration of acetylcholine at cholinergic synapses. The anticholinesterase activity of rivastigmine is relatively specific for brain acetylcholinesterase and butyrylcholinesterase compared with those in peripheral tissues.
🔹 Dosage & Administration
Rivastigmine capsule: Rivastigmine capsule should be administered twice a day, with morning and evening meals.
- Initial dose: Rivastigmine 1.5 mg twice a day.
- Dose titration: The starting dose is Rivastigmine 1.5 mg twice a day. If this dose is well tolerated after a minimum of two weeks of treatment, the dose may be increased to Rivastigmine 3 mg twice a day. Subsequent increases to 4.5 mg and then 6 mg twice a day should also be based on good tolerability of the current dose and may be considered after a minimum of two weeks of treatment at that dose level.
- Maintenance dose: The effective dose is 3 mg to 6 mg twice a day; to achieve maximum therapeutic benefit patients should be maintained on their highest well tolerated dose. The recommended maximum daily dose is 6 mg twice a day. Maintenance treatment can be continued for as long as a therapeutic benefit for the patient exists.
- Re-initiation of therapy: If treatment is interrupted for more than several days, it should be re-initiated at 1.5 mg twice daily. Dose titration should then be carried out as described above.
- Initial Dose: Initiate treatment with 4.6 mg/24 hours Rivastigmine transdermal patch.
- Dose Titration: After a minimum of 4 weeks, if tolerated, increase dose to 9.5 mg/24 hours, which is the minimum effective dose. Following a minimum additional 4 weeks, may increase dosage to maximum dosage of 13.3 mg/24 hours.
- Mild to Moderate Alzheimer's Disease and Parkinson’s Disease Dementia: Rivastigmine transdermal patch 9.5 mg/24 hours or 13.3 mg/24 hours once daily.
- Severe Alzheimer’s Disease: Rivastigmine transdermal patch 13.3 mg/24 hours once daily.
- For treatment interruption longer than 3 days, retitrate dosage starting at 4.6 mg per 24 hours.
🔹 Interaction
As a cholinesterase inhibitor, Exelon Patch 5 may exaggerate the effects of succinylcholine-type muscle relaxants during anaesthesia. Caution is recommended when selecting anaesthetic agents. Possible dose adjustments or temporarily stopping treatment can be considered if needed. In view of its pharmacodynamic effects, rivastigmine should not be given concomitantly with other cholinomimetic substances and might interfere with the activity of anticholinergic medicinal products. No pharmacokinetic interaction was observed between rivastigmine and digoxin, warfarin, diazepam or fluoxetine in studies in healthy volunteers. The increase in prothrombin time induced by warfarin is not affected by administration of rivastigmine. No untoward effects on cardiac conduction were observed following concomitant administration of digoxin and Exelon Patch 5.
🔹 Contraindications
The use of this medicinal product is contraindicated in patients with hypersensitivity to the active substance or other carbamate derivatives.
🔹 Side Effects
The most commonly reported adverse reactions are gastrointestinal, including nausea (38%) and vomiting (23%), especially during titration. Female patients in clinical studies were found to be more susceptible than male patients to gastrointestinal adverse reactions and weight loss.
🔹 Pregnancy & Lactation
For Rivastigmine no clinical data are available. Rivastigmine should not be used during pregnancy unless clearly necessary. In animals, rivastigmine is excreted into milk. It is not known if rivastigmine is excreted into human milk. Therefore, women on rivastigmine should not breast-feed.
🔹 Precautions & Warnings
Patients with sick sinus syndrome or conduction defects, resp diseases. Cholinergic stimulation may increase gastric acid secretion. May exacerbate urinary obstruction and seizures. Pregnancy. Renal impairment, mild to moderate hepatic impairment. Monitor body wt. Asthma or obstructive pulmonary disease. May worsen extrapyramidal symptoms. Lactation.
🔹 Pediatric Usage
Renal and hepatic impairment: Due to increased exposure in moderate renal and mild to moderate hepatic impairment, dosing recommendations to titrate according to individual tolerability should be closely followed
Use in children: Exelon Patch 5 is not recommended for use in children.
Use in children: Exelon Patch 5 is not recommended for use in children.
🔹 Storage Conditions
Store in a cool and dry place, protected from light.
🔍 People also search for
Exelon Patch 5
Exelon Patch 5 Transdermal Patch used for
Exelon Patch 5 side effects
Exelon Patch 5 price
Exelon Patch 5 dose
Exelon Patch 5 Transdermal Patch uses
Is Exelon Patch 5 safe
Exelon Patch 5 dosage
Exelon Patch 5 alternative
Exelon Patch 5 Bangladesh
Rivastigmine Tartrate
Rivastigmine Tartrate price Bangladesh
Transdermal Patch price Bangladesh
Nevian Lifescience PLC
medicine bd
Exelon Patch 5 4.6 mg/24 hr
Exelon Patch 5 4.6 mg/24 hr price
💡 Frequently Asked Questions
Exelon Patch 5 capsule is indicated for the symptomatic treatment of mild to moderately severe Alzheimer's dementia. Symptomatic treatment of mild to moderately severe dementia in patients with Idiopathic Parkinson's disease.
Rivastigmine capsule: Rivastigmine capsule should be administered twice a day, with morning and evening meals.
Initial dose: Rivastigmine 1.5 mg twice a day.
Dose titration: The starting dose is Rivastigmine 1.5 mg twice a day. If this dose is w...
The most commonly reported adverse reactions are gastrointestinal, including nausea (38%) and vomiting (23%), especially during titration. Female patients in clinical studies were found to be more susceptible than male patients to gastrointestinal ad...
User Reviews
⭐
No reviews yet!
Be the first to share your experience.