Mannitol is principally used by IV infusion as an osmotic diuretic to preserve renal function in acute renal failure and to reduce raised intracranial and intraocular pressure. Mannitol is also used as an irrigating solution to prevent hemolysis and hemoglobin buildup during transurethral prostatic resection. It is useful in the management of acute drug poisoning where a route of elimination is through kidney. Besides these, it is also used in symptomatic relief of edema, reperfusion injury, termination of pregnancy, and bowel preparation. So, Mannitol is indicated in-
- Renal insufficiency
- Reperfusion injury
- Raised intracranial pressure
- Bladder irrigation
- Raised intraocular pressure
- Bowel preparation
- Edematous status
- As a prophylactic in renal failure
- Management of poisoning
- Termination of Pregnancy