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The recommended dose: 2.5 mg or 5 mg once daily taken regardless of meals.

Patients with Renal Impairment: No dosage adjustment is recommended for patients with mild renal impairment (creatinine clearance >50 mL/min). The dose is 2.5 mg once daily for patients with moderate or severe renal impairment, or with end-stage renal disease (ESRD) requiring hemodialysis (creatinine clearance < 50 mL/min). Saxagliptin should be administered following hemodialysis. Saxagliptin has not been studied in patients undergoing peritoneal dialysis. Because the dose of Saxagliptin should be limited to 2.5 mg based upon renal function, assessment of renal function is recommended prior to initiation of Saxagliptin and periodically thereafter. Renal function can be estimated from serum creatinine using the Cockcroft-Gault formula or Modification of Diet in Renal Disease formula.

Increased risk of hypoglycaemia with concomitant sulfonylureas, dose reduction may be necessary. Increased serum levels with CYP3A4/5 inhibitors (e.g. atazanavir, ketoconazole, nefazodone, ritonavir). Concomitant CYP3A4 inducers (e.g. carbamazepine, phenobarbital) may reduce the glycaemic lowering effect of Glyza.

Saxagliptin is contraindicated in patients with known hypersensitivity to this drug.

Adverse reactions reported in >5% of patients treated with Glyza and more commonly than in patients treated with placebo are: upper respiratory tract infection, urinary tract infection, and headache. Peripheral edema was reported more commonly in patients treated with the combination of Glyza and a thiazolidinedione (TZD) than in patients treated with the combination of placebo and TZD. Hypoglycemia was reported more commonly in patients treated with the combination of Glyza and sulfonylurea than in patients treated with the combination of placebo and sulfonylurea. Hypersensitivity-related events (e.g.,
urticaria, facial edema) were reported more commonly in patients treated with Glyza than in patients treated with placebo.

Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. Saxagliptin, like other antidiabetic medications, should be used during pregnancy only if clearly needed. It is not known whether Saxagliptin is secreted in human milk. Because many drugs are secreted in human milk, caution should be exercised when Saxagliptin is administered to a nursing woman.

Dosage adjustment of Glyza is not recommended in case of rifampin, diltiazem, amprenavir, aprepitant, erythromycin, fluconazole, fosamprenavir, grapefruit juice, and verapamil. The dose of Glyza should be limited to 2.5 mg when coadministered with ketoconazole, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin.

Store at (at 20-25°C). Protect from light and moisture. Keep out of the reach of the children.

Unit Price: Unit Price: এর কাজ কি Unit Price: খাওয়ার নিয়ম Unit Price: এর দাম কত Unit Price: এর পার্শ্বপ্রতিক্রিয়া Unit Price: কিসের ওষুধ Unit Price: এর ডোজ Unit Price: সম্পর্কে বিস্তারিত Saxagliptin Ibn Sina Pharmaceuticals Ltd. বাংলাদেশের ঔষধ Unit Price: 2.5 mg