Premil
Tablet
Generic Name
Repaglinide
Strength
2 mg
Manufacturer
Beximco Pharmaceuticals Ltd.
Unit Price
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00) Strip Price: ৳ 50.00
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00) Strip Price: ৳ 50.00
✅ In Stock
per unit · Bangladesh
🛒 Buy Now
🔒 Secure checkout · Return & Refund Policy
🔹 Indications
Premil is indicated as an adjunct to diet and exercise to lower the blood glucose in patients with type 2 diabetes mellitus (NIDDM) whose hyperglycemia cannot be controlled satisfactorily by diet and exercise alone. It is also indicated for use in combination with Metformin to lower blood glucose in patients whose hyperglycemia cannot be controlled by exercise, diet, and either Premil or Metformin alone.
🔹 Pharmacology
Repaglinide binds to specific receptors in the cell membrane leading to the closure of ATP dependent K+ channels and the depolarisation of cell membrane. This in turn, leads to Ca++ influx, increased intracellular Ca++ and the stimulation of insulin secretion.
🔹 Dosage & Administration
- For patients not previously treated or whose HbA1c is <8%, the starting dose should be 0.5 mg before each meal.
- For patients previously treated with blood glucose-lowering drugs and whose HbA1c is >8%, the initial dose is 1 or 2 mg before each meal.
- Repaglinide should be taken immediately or up to 30 minutes before each meal.
- Dosage should be adjusted according to response at intervals of 1-2 weeks; up to 4 mg may be given as a single-dose, maximum 16 mg daily.
🔹 Interaction
The dose of Premil may need to be adjusted, if taken with other medications. The possible interactions of Premil with other drugs are:
- Inhibitors of the cytochrome P450 enzyme system (azole antifungals and macrolides) may lead to lower Premil clearance and longer half life.
- Inducers of the cytochrome P450 enzyme system (Rifampin, Phenobarbital, Carbamazepine, Troglitazone, etc.) may accelerate Premil metabolism and shorten its effect.
- Cimetidine has no significant effect on Premil absorption or clearance.
- Premil has no significant effect on Digoxin, Theophyllin, or Warfarin.
- Highly protein bound drugs (e.g., NSAIDs) may increase the plasma level of unbound Premil and potentiate its glucose lowering effect. Thus, co-administration of these drugs with Premil may increase the risk of hypoglycaemia.
- The risk of hypoglycaemia may also be increased when hypoglycaemic agents are co-administered with certain drugs such as salicylates, sulphonamides, Chloramphenicol, coumarins, Probenecid, monoamine oxidase (MAO) inhibitors, and adrenergic blockers.
🔹 Contraindications
Repaglinide is contraindicated in patients with:
- Diabetic ketoacidosis, with or without coma.
- Type 1 diabetes mellitus and
- Known hypersensitivity to the drug or its inactive ingredients.
🔹 Side Effects
The most common side effects of Premil are hypoglycemia and related symptoms. Others include upper respiratory tract infections, diarrhea, constipation, nausea and vomiting. Hypersensitivity reactions include rashes and urticaria.
🔹 Pregnancy & Lactation
Safety in pregnant women has not been established. Repaglinide should be used during pregnancy only if it is clearly needed. It is not known whether Repaglinide is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Repaglinide, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
🔹 Precautions & Warnings
Insulin should be substituted during concurrent illness (such as myocardial infarction, coma, infection, and trauma) and during surgery. All oral blood glucose-lowering drugs are capable of producing hypoglycemia. Premil should be administered with meals to lessen the risk of hypoglycemia.
🔹 Storage Conditions
Do not store above 30°C. Keep away from light and out of the reach of children.
🔍 People also search for
💡 Frequently Asked Questions
Premil is indicated as an adjunct to diet and exercise to lower the blood glucose in patients with type 2 diabetes mellitus (NIDDM) whose hyperglycemia cannot be controlled satisfactorily by diet and exercise alone. It is also indicated for use in co...
For patients not previously treated or whose HbA1c is 8%, the initial dose is 1 or 2 mg before each meal.
Repaglinide should be taken immediately or up to 30 minutes before each meal.
Dosage should be adjusted according to response at intervals o...
The most common side effects of Premil are hypoglycemia and related symptoms. Others include upper respiratory tract infections, diarrhea, constipation, nausea and vomiting. Hypersensitivity reactions include rashes and urticaria....
User Reviews
⭐
No reviews yet!
Be the first to share your experience.