Skycillin is indicated in the treatment of infections caused by susceptible strains of the designated organism listed below:
Infections of the Genitourinary Tract Including Gonorrhea: E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, and nonpenicillinase-producing N. gononhoeae.
Skycillin is indicated in the treatment of infections caused by susceptible strains of the designated organism listed below:
Infections of the Genitourinary Tract Including Gonorrhea: E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, and nonpenicillinase-producing N. gononhoeae.
🔹Pharmacologyফার্মাকোলজি
Ampicillin inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
Ampicillin inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
🔹Dosage & Administrationমাত্রা ও ব্যবহারবিধি
Intra-articular: Supplement in systemic therapy for treatment of susceptible infections-
Adult: 500 mg daily.
Child: <10 yr Half of adult routine dosage.
Intraperitoneal: Supplement in systemic therapy for treatment of susceptible infections-
Adult: 500 mg daily.
Child: <10 yr Half of adult routine dosage.
Intrapleural: Supplement in systemic therapy for treatment of susceptible infections-
Adult: 500 mg daily.
Child: <10 yr Half of adult routine dosage
Intravenous: Meningitis-
Adult: 2 gm 6 hrly.
Child: 150 mg/kg daily in divided doses.
Intrapartum prophylaxis against group B Streptoccocal infection in neonates-
Adult: Initially, 2 gm via IV inj followed by 1 gm 4 hrly until delivery.
Adult: 1-2 gm 6 hrly for 2 wk in acute infections, and 4-12 wk in carriers.
Uncomplicated gonorrhoea-
Adult: 2 gm with 1 gm of probenecid as single dose, recommended to be repeated in female patients.
Urinary tract infections-
Adult: 500 mg 8 hrly.
Parenteral: Susceptible infections-
Adult: 500 mg 6 hrly, via IM or slow IV inj over 3-5 min or by infusion.
Child: <10 yr Half of adult routine dosage.
Septicaemia-
Adult: 150-200 mg/kg daily. Initiate with IV admin for at least 3 days, then continue with IM inj 3-4 hrly. Continue treatment for at least 48-72 hr after the patient has become asymptomatic or when there is evidence of bacterial eradication. Recommended treatment duration for infections caused by group-A β-haemolytic streptococci: At least 10-days, to prevent occurrence of acute rheumatic fever or acute glomerulonephritis.
Child: Same as adult dose.
Intra-articular: Supplement in systemic therapy for treatment of susceptible infections-
Adult: 500 mg daily.
Child: <10 yr Half of adult routine dosage.
Intraperitoneal: Supplement in systemic therapy for treatment of susceptible infections-
Adult: 500 mg daily.
Child: <10 yr Half of adult routine dosage.
Intrapleural: Supplement in systemic therapy for treatment of susceptible infections-
Adult: 500 mg daily.
Child: <10 yr Half of adult routine dosage
Intravenous: Meningitis-
Adult: 2 gm 6 hrly.
Child: 150 mg/kg daily in divided doses.
Intrapartum prophylaxis against group B Streptoccocal infection in neonates-
Adult: Initially, 2 gm via IV inj followed by 1 gm 4 hrly until delivery.
Adult: 1-2 gm 6 hrly for 2 wk in acute infections, and 4-12 wk in carriers.
Uncomplicated gonorrhoea-
Adult: 2 gm with 1 gm of probenecid as single dose, recommended to be repeated in female patients.
Urinary tract infections-
Adult: 500 mg 8 hrly.
Parenteral: Susceptible infections-
Adult: 500 mg 6 hrly, via IM or slow IV inj over 3-5 min or by infusion.
Child: <10 yr Half of adult routine dosage.
Septicaemia-
Adult: 150-200 mg/kg daily. Initiate with IV admin for at least 3 days, then continue with IM inj 3-4 hrly. Continue treatment for at least 48-72 hr after the patient has become asymptomatic or when there is evidence of bacterial eradication. Recommended treatment duration for infections caused by group-A β-haemolytic streptococci: At least 10-days, to prevent occurrence of acute rheumatic fever or acute glomerulonephritis.
Child: Same as adult dose.
🔹Interactionমিথস্ক্রিয়া
May reduce the efficacy of oral contraceptives. May alter INR while on warfarin and phenindione. May reduce the efficacy of oral typhoid vaccines. May reduce the excretion of methotrexate. Reduced excretion with probenecid and sulfinpyrazone, resulting to increased risk of toxicity. Allopurinol increases ampicillin-induced skin reactions. Reduced absorption with chloroquine. Bacteriostatic antibacterials (e.g. erythromycin, chloramphenicol, tetracycline) may interfere with the bactericidal action of ampicillin.
May reduce the efficacy of oral contraceptives. May alter INR while on warfarin and phenindione. May reduce the efficacy of oral typhoid vaccines. May reduce the excretion of methotrexate. Reduced excretion with probenecid and sulfinpyrazone, resulting to increased risk of toxicity. Allopurinol increases ampicillin-induced skin reactions. Reduced absorption with chloroquine. Bacteriostatic antibacterials (e.g. erythromycin, chloramphenicol, tetracycline) may interfere with the bactericidal action of ampicillin.
🔹Contraindicationsপ্রতিনির্দেশনা
Hypersensitivity to ampicillin and other penicillins.
Hypersensitivity to ampicillin and other penicillins.
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
🔹Precautions & Warningsসতর্কতা
Patient with history of β-lactam allergy. During renal impairment, Pregnancy and lactation.
Patient with history of β-lactam allergy. During renal impairment, Pregnancy and lactation.
🔹Pediatric Usageশিশুদের ক্ষেত্রে ব্যবহার
Renal Impairment: CrCl<10: Dose reduction or increase in dose interval.
Renal Impairment: CrCl<10: Dose reduction or increase in dose interval.
🔹Storage Conditionsসংরক্ষণ
Store between 20-25° C. Reconstituted oral susp: Store between 2-8° C (discard after 14 days).
Store between 20-25° C. Reconstituted oral susp: Store between 2-8° C (discard after 14 days).
Skycillin is indicated in the treatment of infections caused by susceptible strains of the designated organism listed below:
Infections of the Genitourinary Tract Including Gonorrhea: E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and ot...
Intra-articular:Supplement in systemic therapy for treatment of susceptible infections-
Adult: 500 mg daily.
Child:
