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Clocef

Powder for Suspension

🧬 Cefaclor Monohydrate 🏢 Amico Laboratories Ltd.
Generic Name Cefaclor Monohydrate
Strength 125 mg/5 ml
Manufacturer Amico Laboratories Ltd.
Unit Price 100 ml bottle: ৳ 175.00
100 ml bottle: ৳ 175.00 ✅ In Stock per unit · Bangladesh
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🔹 Indications

🔹 Pharmacology

Cefaclor is a second generation cephalosporin antibiotic which has stability against b-lactamase inactivation and possesses a broad spectrum of activity. Cefaclor is active against the following organisms in vitro: Alpha and beta haemolytic Streptococci, Staphylococci; including coagulase-positive, coagulase negative and penicillinase-producing strains, Streptococcus pneumoniae, Streptococcus pyogenes (Group A b-haemolytic Streptococci), Branhamella catarrhalis, Escherichia coli, Proteus mirabilis, Klebsiella species Haemophilus influenzae, including ampicillin-resistant strains. Cefaclor is generally effective in the eradication of Streptococci from the nasopharynx.

🔹 Dosage & Administration

Capsule: Adult dose: The usual dose is 250 mg every 8 hourly. For severe infections or those caused by less susceptible organisms, doses may be doubled with a maximum dosage of 4 g/day. In case of β-hemolytic Streptococcal infections, therapy should be administered for at least 10 days.

Powder for suspension & Pediatric drops: Children: The usual daily dosage for paediatric patients over 1 month is 20 mg/kg/day in divided doses every 8 hours. In serious infections such as otitis media and infections caused by less susceptible organisms, 40 mg/kg/day are recommended, with a maximum dosage of 1 g/day. Safety and effectiveness of Cefaclor for use in infants less than 1 month of age have not been established.

<1 year (9 kg):
  • Powder for suspension: ½ tsp three times daily
  • Pediatric drops: 0.625 ml three times daily
1-5 years (9 kg-18 kg):
  • Powder for suspension: 1 tsp three times daily
  • Pediatric drops: 1.25 ml three times daily
Over 5 years:
  • Powder for suspension: 2 tsp three times daily
In renal impairment: Cefaclor may be administered in the presence of impaired renal function. Dose adjustments for patients with moderate or sever renal impairment are not usually required.

In patients undergoing haemodialysis: Haemodialysis shortens serum half-life by 25-30%. In patients undergoing haemodialysis, a predialysis loading dose of 250 mg-1 g is recommended. A maintaining dose of 250-500 mg every 6 hourly during interdialytic period may be used.

Geriatric use: Clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

🔹 Interaction

Clocef may show a false-positive reaction for glucose in the urine with tests that use Benedict's solution, Fehling's solutions. When Clocef and oral anticoagulants were administered concomitantly there have been reports of increased anticoagulant effect and there have been rare reports of increased prothrombin time, with or without clinical bleeding, in patients receiving Clocef and anticoagulants (Warfarin) concomitantly. It is recommended that in such patients, regular monitoring of prothrombin time should be considered, with adjustment of dosage if necessary.

🔹 Contraindications

Cefaclor is contraindicated in patients with known allergy to the Cephalosporin group of antibiotics.

🔹 Side Effects

Gastro-intestinal symptoms may occur include diarrhea, nausea and vomiting in some patients receiving Clocef. As with some penicillins and some other Cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely. Fever, abdominal pain, superinfection, renal dysfunction, toxic nephropathy, hemorrhage, elevated LDH and pancytopenia may occur.

🔹 Pregnancy & Lactation

There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Small amounts of Cefaclor have been detected in mother's milk. The effect on nursing infants is not known. Caution should be exercised when Cefaclor is administered to a nursing woman.

🔹 Precautions & Warnings

Prescribing Clocef in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Prolonged use of Clocef may result in the overgrowth of nonsusceptible organisms. If superinfection occurs during therapy, appropriate measures should be taken. As with other β-lactam antibiotics, the renal excretion of Clocef is inhibited by Probenecid. Antibiotics, including Cephalosporins, should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.

Before therapy with Clocef is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to Clocef, Cephalosporins, Penicillins or other drugs. If Clocef is to be given to penicillin-sensitive patients, caution should be exercised. Clocef should be administered cautiously to any patient who has demonstrated some form of allergy, particularly to drugs.

🔹 Storage Conditions

Store at room temperature and protect from light. After reconstitution the suspension can be used within 7 days if kept at room temperature and within 14 days if kept in refrigerator (2-8°C). Always keep the bottle tightly closed.

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💡 Frequently Asked Questions

Clocef is indicated for the treatment of the following infections: Respiratory tract infections, including pneumonia, bronchitis, caused by Streptococcus Pneumoniae, Haemophilus Influenzae, and Streptococcus Pyogenes Otitis media caused by Strept...
Capsule: Adult dose: The usual dose is 250 mg every 8 hourly. For severe infections or those caused by less susceptible organisms, doses may be doubled with a maximum dosage of 4 g/day. In case of β-hemolytic Streptococcal infections, therapy should...
Gastro-intestinal symptoms may occur include diarrhea, nausea and vomiting in some patients receiving Clocef. As with some penicillins and some other Cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely. Fever, abdom...

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